DESTINY-Endometrial01: A Phase III Study of Trastuzumab Deruxtecan Plus Rilvegostomig or Pembrolizumab as First-Line Treatment of HER2-Expressing (IHC 3+/2+), Mismatch Repair Proficient (pMMR) Endometrial Cancer

Trial Identifier: D781DC00001
Sponsor: AstraZeneca
Collaborator:
Daiichi Sankyo Company, Ltd.
Gynecologic Oncology Group (GOG) Foundation Inc.
European Network for Gynaecological Oncological Trial Groups (ENGOT)
Start Date: March 2025
Primary Completion Date: January 2029
Study Completion Date: February 2031
Condition: Endometriosis

Available Languages

For questions about your Trial Results Summary, please see Sponsor contact section within your Trial Results Summary.

No documents have been posted yet.

Trial Locations

Country Location
AT Innsbruck, AT, 6020
AT Linz, AT, 4021
AT Vienna, AT, 1090
AT Wein, AT, 1130
AU Blacktown, AU, 2148
AU East Melbourne, AU, 3002
AU Nedlands, AU, 6009
AU South Brisbane, AU, 4101
BE Anderlecht, BE, 1070
BE Brussel, BE, 1200
BE Gent, BE, 9000
BE Leuven, BE, 3000
BE Liège, BE, 4000
BR Barretos, BR, 14784-057
BR Belo Horizonte, BR, 30130 100
BR Goiânia, BR, 74000-000
BR Londrina, BR, 86015-520
BR Porto Alegre, BR, 90610000
BR Porto Alegre, BR, 90020-090
BR Rio de Janeiro, BR, 20220-410
BR Salvador, BR, 41.950-610
BR Sao Paulo, BR, 01246-000
BR São Paulo, BR, 01317-001
BR São Paulo, BR, 1409
BR Teresina, BR, 64049-200
CA, AB Edmonton, AB, CA, T6G 1Z2
CA, Alberta Calgary, Alberta, CA, T2N 5G2
CA, MB Winnipeg, MB, CA, R3E 0V9
CA, ON London, ON, CA, N6A 4L6
CA, ON Toronto, ON, CA, M4N 3M5
CA, ON Toronto, ON, CA, M5G 2M9
CA, QC Montreal, QC, CA, H1T 2M4
CA, QC Montréal, QC, CA, H3G 1A4
CA, QC Québec, QC, CA, G1J 4Z1
CA, Quebec Montréal, Quebec, CA, H2X 0A9
CH Liestal, CH, CH- 4410
CH St. Gallen, CH, 9007
CH Zürich, CH, 8091
CN Beijing, CN, 100142
CN Changchun, CN, 130021
CN Changsha, CN, 410013
CN Chengdu, CN, 610072
CN Chengdu, CN, 610041
CN Chongqing, CN, 400030
CN Fuzhou, CN, 350001
CN Fuzhou, CN, 350014
CN guangzhou, CN, 510080
CN Guangzhou, CN, 510060
CN Guangzhou, CN, 510120
CN haikou city, CN, 570311
CN Hangzhou, CN, 310022
CN Harbin, CN, 150049
CN Hefei, CN, 230001
CN Jinan, CN, 250021
CN Jinan, CN, 250117
CN Jining, CN, 272029
CN Kunming, CN, 650118
CN Lanzhou, CN, 730030
CN Nanchang, CN, 330006
CN Nanning, CN, 530021
CN shanghai, CN, 200011
CN Shanghai, CN, 201318
CN Shantou, CN
CN Shenyang, CN, 110004
CN Shenyang, CN, 110042
CN Taiyuan, CN, 030001
CN Tianjin, CN, 300060
CN Wuhan, CN, 430000
CN Wuhan, CN, 430022
CN Xian, CN, 710061
CN Xuzhou, CN, 221009
CN Yibin, CN, 610500
DE Berlin, DE, 13353
DE Chemnitz, DE, 09116
DE Dessau-Roßlau, DE, 06847
DE Dresden, DE, 01307
DE Essen, DE, 45147
DE Hamburg, DE, 20246
DE Kassel, DE, 34125
DE Leipzig, DE, 04103
DE Mannheim, DE, 68167
DE Marburg, DE, 35043
DE Münster, DE, 48149
DE Saarbrücken, DE, 66113
DK Aalborg, DK, 9100
DK København Ø, DK, 2100
DK Odense, DK, 5000
ES A Coruña, ES, 15009
ES Córdoba, ES, 14004
ES El Palmar, ES, 30120
ES L'Hospitalet de Llobregat, ES, 08908
ES Madrid, ES, 28034
ES Madrid, ES, 28041
ES Palma de Mallorca, ES, 07010
ES San Sebastian, ES, 20014
ES Valencia, ES, 46006
ES Valencia, ES, 46009
ES Zaragoza, ES, 50009
FI Helsinki, FI, 00290
FI Oulu, FI, 90029
FI Tampere, FI, 33520
FI Turku, FI, 20520
FR Besançon Cedex, FR, 25030
FR Bordeaux, FR, 33076
FR Caen cedex 05, FR, 14076
FR Clermont-Ferrand, FR, 63000
FR Lyon, FR, 69373
FR Montpellier, FR, 34298
FR Nice, FR, 06100
FR Paris, FR, 75015
FR PLERIN, FR, 22190
FR Poitiers, FR, 86021
FR Saint Herblain, FR, 44805
FR Toulouse, FR, 31059
GB Bath, GB, BA1 3NG
GB Cambridge, GB, CB2 0QQ
GB Leeds, GB, LS9 7TF
GB London, GB, EC1A 7BE
GB Manchester, GB, M20 4BX
GB Northwood, GB, HA6 2RN
GB Taunton, GB, TA1 5DA
HU Budapest, HU, 1122
HU Budapest, HU, 1088
HU Debrecen, HU, 4032
IT Catania, IT, 95100
IT Firenze, IT, 50134
IT Milan, IT, 20159
IT Milan, IT, 20141
IT Milano, IT, 20162
IT Monza, IT, 20900
IT Napoli, IT, 80131
IT Reggio Emilia, IT, 422122
IT Roma, IT, 00144
IT Rome, IT, 00168
IT Torino, IT, 10128
IT Turin, IT, 10128
JP Akashi-shi, JP, 673-8558
JP Ginowan-shi, JP, 901-2725
JP Hidaka-shi, JP, 350-1298
JP Isehara-shi, JP, 259-1193
JP Kashiwa, JP, 227-8577
JP Kashiwa-shi, JP, 277‐8567
JP Kobe-shi, JP, 650-0047
JP Koto-ku, JP, 135-8550
JP Kurume-shi, JP, 830-0011
JP Matsuyama-shi, JP, 791-0280
JP Morioka-shi, JP, 028-3695
JP Nagoya-shi, JP, 464-8681
JP Niigata-shi, JP, 951-8520
JP Osaka-shi, JP, 541-8567
JP Ota-shi, JP, 373-8550
JP Sapporo-shi, JP, 060-8638
JP Sendai-shi, JP, 980-8574
JP Shinjuku-ku, JP, 160-8582
JP Sunto-gun, JP, 411-8777
JP Tokyo, JP, 104-0045
KR Goyang-si, KR, 10408
KR Seoul, KR, 05505
KR Seoul, KR, 03722
KR Seoul, KR, 06351
KR Seoul, KR, 03080
KR Suwon-si, KR, 16499
NO Oslo, NO, 0379
NO Stavanger, NO, 4011
PL Białystok, PL, 15-027
PL Gdańsk, PL, 80-214
PL Łódź, PL, 93-338
PL Poznan, PL, 60-569
PL Siedlce, PL, 08-110
PL Szczecin, PL, 70-111
SE Linköping, SE, 581 85
SE Lund, SE, 22185
SE Stockholm, SE, 17164
SE Uppsala, SE, 751 85
TW Changhua, TW, 500
TW Kaohsiung, TW, 81362
TW New Taipei, TW, 220
TW Taichung, TW, 40705
TW Tainan, TW, 704
TW Taipei, TW, 10449
US, AR Little Rock, AR, US, 72205
US, CA Duarte, CA, US, 91010
US, CA La Jolla, CA, US, 92037
US, CA San Francisco, CA, US, 94143
US, FL Fort Myers, FL, US, 33901
US, FL Miami Beach, FL, US, 33140
US, FL Saint Petersburg, FL, US, 33705
US, FL Tampa, FL, US, 33612
US, FL West Palm Beach, FL, US, 33401
US, GA Augusta, GA, US, 30912
US, IL Arlington Heights, IL, US, 60005
US, IL Evanston, IL, US, 60201
US, LA Shreveport, LA, US, 71103
US, MA Boston, MA, US, 02111
US, MA Worcester, MA, US, 01655
US, MD Baltimore, MD, US, 21201
US, MI Ann Arbor, MI, US, 48109
US, MN Minneapolis, MN, US, 55455
US, MN Rochester, MN, US, 55905
US, MO Saint Louis, MO, US, 63141
US, MO Springfield, MO, US, 65804
US, MS Jackson, MS, US, 39216
US, NC Charlotte, NC, US, 28204
US, NC Winston Salem, NC, US, 27103
US, NJ Hackensack, NJ, US, 07601
US, NM Albuquerque, NM, US, 87109
US, NY New York, NY, US, 10065
US, OH Cincinnati, OH, US, 45220
US, OH Columbus, OH, US, 43210
US, OR Eugene, OR, US, 97401
US, PA Philadelphia, PA, US, 19111
US, PA Pittsburgh, PA, US, 15224
US, RI Providence, RI, US, 02905
US, SC Charleston, SC, US, 29425
US, SD Sioux Falls, SD, US, 57105
US, TX Austin, TX, US, 78758
US, TX Fort Worth, TX, US, 76104
US, TX Houston, TX, US, 77030
US, TX San Antonio, TX, US, 78240
US, VA Charlottesville, VA, US, 22908
US, VA Fairfax, VA, US, 22031
US, VT Saint Johnsbury, VT, US, 05819
US, WI Madison, WI, US, 53705